Marina, GCP. Seems to be a conveinient location, quick trip to almost anywhere. Lots of good resturants, cambios, farmacias, and within walking distance to large supermercados.
Playa de Oro aka Club Crown Paradise,
Hotel Zone. Off the main road, but on the beach....quiet and convenient to downtown. Close to marina, shopping and Pittial. My choice, avoid the busy crowded streets and restuarants. And I love watching the confusion of tourists coming off of the cruise ships.